Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer

The pyruvate transporter MPC1 (mitochondrial pyruvate carrier 1) acts as a tumour-suppressor, loss of which correlates with a pro-tumorigenic phenotype and poor survival in several tumour types. In high-grade serous ovarian cancers (HGSOC), patients display copy number loss of MPC1 in around 78% of...

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Detalhes bibliográficos

Principais autores:	M. Rufaik Farook, Zack Croxford, Steffan Morgan, Anthony D. Horlock, Amy K. Holt, April Rees, Benjamin J. Jenkins, Carmen Tse, Emma Stanton, D. Mark Davies, Catherine A. Thornton, Nicholas Jones, I. Martin Sheldon, Emma E. Vincent, James G. Cronin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-03-01
Colecção:	Molecular Metabolism
Assuntos:	Proline High grade serous ovarian cancer PYCR1 PYCR2 PYCR3 Mitochonrial pyruvate carrier
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2212877824000310
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