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Targeted CSF metabolomics and conformal prediction improve diagnostic accuracy of normal pressure hydrocephalus

Abstract Background and objectives Idiopathic normal pressure hydrocephalus (iNPH) is a progressive but treatable neurological disorder. Yet, diagnosis is often confounded by overlapping symptoms and biomarker profiles with Alzheimer’s disease (AD), mild cognitive impairment (MCI), and frontotempora...

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Kaydedildi:
Asıl Yazarlar: Ulrika Hofling, Jenny Jakobsson, Ida Erngren, Oskar Ekman, Eva Freyhult, Akshai Parakkal Sreenivasan, Jakob Siljebo, Sylwia Libard, Lena Kilander, Malin Löwenmark, Martin Ingelsson, Kim Kultima, Johan Virhammar
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2026-02-01
Seri Bilgileri:Fluids and Barriers of the CNS
Konular:
iNPH
CSF
Metabolomics
Biomarkers
LC-MS
Neurodegeneration
Online Erişim:https://doi.org/10.1186/s12987-026-00771-z
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