Association Between Nitric Oxide, Oxidative Stress, Eryptosis, Red Blood Cell Microparticles, and Vascular Function in Sickle Cell Anemia

Chronic hemolysis, enhanced oxidative stress, and decreased nitric oxide (NO) bioavailability promote vasculopathy in sickle cell anemia (SCA). Oxidative stress and NO are known to modulate eryptosis in healthy red blood cells (RBCs); however, their role in SCA eryptosis and their impact on the gene...

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Autors principals:	Elie Nader, Marc Romana, Nicolas Guillot, Romain Fort, Emeric Stauffer, Nathalie Lemonne, Yohann Garnier, Sarah Chambers Skinner, Maryse Etienne-Julan, Mélanie Robert, Alexandra Gauthier, Giovanna Cannas, Sophie Antoine-Jonville, Benoît Tressières, Marie-Dominique Hardy-Dessources, Yves Bertrand, Cyril Martin, Céline Renoux, Philippe Joly, Marijke Grau, Philippe Connes
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2020-11-01
Col·lecció:	Frontiers in Immunology
Matèries:	sickle cell anemia eryptosis red blood cell microparticles vascular dysfunction endothelial cells TLR4
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.551441/full
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