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Optimized culture of primary human alveolar type II cell–derived 3D organoids from fibrotic lung tissue with phenotypic and metabolic profiling

Abstract Background Alveolar type II (AT-II) epithelial cells are essential for alveolar repair, immune regulation, and surfactant secretion. Despite their promise for pulmonary disease modeling, limited access and culture methods hinder translational use. We established a patient-derived 3D AT-II o...

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Main Authors: Lara-Jasmin Schröder, Julia Rückoldt, Stephanie Schubert, Lars Knudsen, Sabina-Marija Janciauskiene, Christopher Werlein, Mareike Knoll, Regina Engelhardt, Christina Petzold-Mügge, Jonas C. Schupp, Marius M. Hoeper, Jens Gottlieb, Fabio Ius, Patrick Zardo, Marc Lindenberg, Christian Riehle, Lavinia Neubert, Jan C. Kamp
Format: Artigo
Language:Inglês
Published: BMC 2026-03-01
Series:Respiratory Research
Subjects:
Alveolar type II cells
Lung epithelium
Lung organoids
Alveolosphere
Idiopathic pulmonary fibrosis
Human lung explant
Online Access:https://doi.org/10.1186/s12931-026-03610-9
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