ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation

Abstract Senescence-associated secretory phenotype (SASP) mediates the biological effects of senescent cells on the tissue microenvironment and contributes to ageing-associated disease progression. ACSS2 produces acetyl-CoA from acetate and epigenetically controls gene expression through histone ace...

Whakaahuatanga katoa

I tiakina i:

Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua:	Li Yang, Jianwei You, Xincheng Yang, Ruishu Jiao, Jie Xu, Yue zhang, Wen Mi, Lingzhi Zhu, Youqiong Ye, Ruobing Ren, Delin Min, Meilin Tang, Li Chen, Fuming Li, Pingyu Liu
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Portfolio 2025-02-01
Rangatū:	Nature Communications
Urunga tuihono:	https://doi.org/10.1038/s41467-025-57334-3
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!

ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation

Ngā tūemi rite