JAK inhibitor tofacitinib alleviates secretory dysfunction and Th17/Treg imbalance in a Sjögren’s disease murine model

Objectives To examine whether the JAK inhibitor tofacitinib alleviates secretory dysfunction and modulates Th17/Treg balance in a Sjögren’s disease (SjD) murine model.Methods Integrated analysis of SjD transcriptome sequencing (GSE159574, GSE247662) identified key signalling pathways, potential ther...

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Autores principales:	Yanjun Lin, Yanjing Ou, Jingjing Su, Jianghan Xu, Chaowei Liu, Kaixun He, Lin Zhou, Dong Wu, Jiang Chen
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis Group 2026-12-01
Colección:	Annals of Medicine
Materias:	Sjögren’s disease transcriptome tofacitinib JAK-STAT signalling pathway Th17/treg balance
Acceso en línea:	https://www.tandfonline.com/doi/10.1080/07853890.2026.2625552
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