PCAF-mediated acetylation regulates RAD51 dynamic localization on chromatin during HR repair

Abstract PCAF (p300-associated factor), a major histone acetyltransferase, is involved in many metabolic and pathogenic diseases. Here, we reveal a novel function of PCAF in homologous recombination repair (HR). We demonstrate that RAD51, a core protein in HR repair, physically interacts with the ac...

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Autori principali:	Jiajia Hou, Munan Shi, Jialu Hong, Yuting Liu, Xinyi Song, Haipeng Rao, Ying Ma, Chunchun Huang, Zhigang Hu, Lingfeng He, Zhigang Guo, Feiyan Pan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer Nature 2025-07-01
Serie:	EMBO Reports
Soggetti:	RAD51 PCAF Homologous Recombination Protein Stability
Accesso online:	https://doi.org/10.1038/s44319-025-00513-6
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