Suppression of CPSF6 Enhances Apoptosis Through Alternative Polyadenylation-Mediated Shortening of the VHL 3′UTR in Gastric Cancer Cells

Alternative polyadenylation (APA) is an important RNA post-transcriptional process, which can generate diverse mRNA isoforms. Increasing evidence shows that APA is involved in cell self-renewal, development, immunity, and cancer. CPSF6 is one of the core proteins of CFIm complex and can modulate the...

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Autors principals:	Xinglong Shi, Keshuo Ding, Qiang Zhao, Pengxiao Li, Yani Kang, Sheng Tan, Jielin Sun
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2021-09-01
Col·lecció:	Frontiers in Genetics
Matèries:	alternative polyadenylation gastric cancer apoptosis CPSF6 VHL
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fgene.2021.707644/full
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