Flexible pri-miRNA structures enable tunable production of 5’ isomiRs
The Drosha cleavage of a pri-miRNA defines mature microRNA sequence. Drosha cleavage at alternative positions generates 5’ isoforms (isomiRs) which have distinctive functions. To understand how pri-miRNA structures influence Drosha cleavage, we performed a systematic analysis of the maturation of en...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Taylor & Francis Group
2022-12-01
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| Σειρά: | RNA Biology |
| Θέματα: | |
| Διαθέσιμο Online: | http://dx.doi.org/10.1080/15476286.2022.2025680 |
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