Puerarin pretreatment provides protection against myocardial ischemia/reperfusion injury via inhibiting excessive autophagy and apoptosis by modulation of HES1

Abstract The study aimed to elucidate the underlying pharmacological mechanism of the traditional Chinese medicine Pue in ameliorating myocardial ischemia-reperfusion injury (MIRI), a critical clinical challenge exacerbated by reperfusion therapy. In vivo MIRI and in vitro anoxia/reoxygenation (A/R)...

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Detalhes bibliográficos

Principais autores:	Yong Yuan, Songqing Lai, Tie Hu, Fajia Hu, Chenchao Zou, Xiuqi Wang, Ming Fang, Jichun Liu, Huang Huang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-01-01
Colecção:	Scientific Reports
Assuntos:	Myocardial ischemia/reperfusion injury Puerarin HES1 Autophagy Apoptosis
Acesso em linha:	https://doi.org/10.1038/s41598-024-84808-z
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