Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1

Abstract Background Nuclear receptors NUR77 and NOR1 were identified as critical targets in acute myeloid leukemia (AML) therapy. Previously, we showed that Z-ligustilide (Z-LIG) selectively targeted AML by restoring NUR77 and NOR1. However, its downstream mechanisms are yet to be elucidated. Method...

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Автори:	Gen Liu, Zhi-gang Chen, Li-rong Yang, Yu-xia Rong, Qin Wang, Li Li, Qian-wei Lu, Ming-dong Jiang, Hong-yi Qi
Формат:	Artigo
Мова:	Inglês
Опубліковано:	BMC 2023-09-01
Серія:	Chinese Medicine
Предмети:	Z-ligustilide Acute myeloid leukemia NUR77 NOR1 Mitochondrial dysfunction
Онлайн доступ:	https://doi.org/10.1186/s13020-023-00808-7
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