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Loss of Cdx2 expression in primary tumors and lymph node metastases is specific for mismatch repair-deficiency in colorectal cancer

Background: Approximately 20% of all colorectal cancers are hypothesized to arise from the serrated pathway characterized by mutation in BRAF, high-level CpG Island Methylator Phenotype (CIMP) and microsatellite instability/mismatch repair (MMR)-deficiency. MMR-deficient cancers show frequent losses...

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Principais autores: Heather eDawson, Viktor Hendrik Koelzer, Anne eLukesh, Makhmudbek eMallaev, Daniel eInderbitzin, Alessandro eLugli, Inti eZlobec
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2013-10-01
Serier:Frontiers in Oncology
Fag:
Lymph Nodes
Microsatellite Instability
colorectal cancer
mismatch repair
ROC Curve
Cdx2
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00265/full
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