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Butyrate induces apoptosis in murine macrophages via caspase-3, but independent of autocrine synthesis of tumor necrosis factor and nitric oxide

We demonstrated that 4 mM butyrate induces apoptosis in murine peritoneal macrophages in a dose- and time-dependent manner as indicated by studies of cell viability, flow cytometric analysis of annexin-V binding, DNA ladder pattern and the determination of hypodiploid DNA content. The activity of ca...

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Tallennettuna:
Päätekijät: Ramos M.G., Rabelo F.L.A., Duarte T., Gazzinelli R.T., Alvarez-Leite J.I.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Associação Brasileira de Divulgação Científica 2002-01-01
Sarja:Brazilian Journal of Medical and Biological Research
Aiheet:
Butyrate
Apoptosis
Caspase
Nitric oxide
Cytokine
Macrophage
Linkit:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000200004
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