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Identification of genomic enhancers through spatial integration of single‐cell transcriptomics and epigenomics

Abstract Single‐cell technologies allow measuring chromatin accessibility and gene expression in each cell, but jointly utilizing both layers to map bona fide gene regulatory networks and enhancers remains challenging. Here, we generate independent single‐cell RNA‐seq and single‐cell ATAC‐seq atlase...

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Hoofdauteurs: Carmen Bravo González‐Blas, Xiao‐Jiang Quan, Ramon Duran‐Romaña, Ibrahim Ihsan Taskiran, Duygu Koldere, Kristofer Davie, Valerie Christiaens, Samira Makhzami, Gert Hulselmans, Maxime de Waegeneer, David Mauduit, Suresh Poovathingal, Sara Aibar, Stein Aerts
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Nature 2020-05-01
Reeks:Molecular Systems Biology
Onderwerpen:
enhancer detection
eye‐antennal disc
gene regulation
single‐cell omics
spatial integration
Online toegang:https://doi.org/10.15252/msb.20209438
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