Inflammatory macrophage-derived plasminogen activator inhibitor-1 exacerbates inflammation through efferocytosis inhibition

Abstract Plasminogen activator inhibitor-1 (PAI-1) is significantly upregulated during inflammatory responses, and elevated PAI-1 levels are associated with poor prognosis in various diseases. However, the precise mechanism through which PAI-1 exacerbates inflammation remains unclear. In the present...

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Principais autores:	Abd Aziz Ibrahim, Hiromi Miura, Tomoya Terada, Masaki Kawarada, Nobuo Watanabe, Hiroyuki Hosokawa, Masato Ohtsuka, Toshio Miyata, Takashi Yahata
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 2026-03-01
Series:	Cell Death Discovery
Acceso en liña:	https://doi.org/10.1038/s41420-026-03076-0
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