Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment

Abstract Cisplatin-induced neurotoxicity is one of the limiting factors to its use especially in tumors that demand high drug dosage. One of the Cisplatin pathways is ferritinophagy which may end up in ferroptosis. So, we aimed to use iron chelator as a new strategy based on an anti-ferroptotic mech...

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Principais autores:	Hanan Seddiek, Mira Hanna, Amany Elsayed Mohamed Hamoud, Marawan Abd Elbaset, Ahmed M. A. Akabawy, Mohamed Zakaria Kotb, Mohamed Mansour Khalifa
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-02-01
coleção:	Scientific Reports
Assuntos:	Cisplatin Neurotoxicity Deferiprone Ferritinophagy Ferroptosis
Acesso em linha:	https://doi.org/10.1038/s41598-025-87628-x
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