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Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis

<p>Abstract</p> <p>Background</p> <p>Stress of the endoplasmic reticulum (ER) leading to activation of the unfolded protein response (UPR) and alveolar epithelial cell (AEC) apoptosis may play a role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Our objectives were to determine whether...

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Principais autores: Cha Seung-Ick, Ryerson Christopher J, Lee Joyce S, Kukreja Jasleen, Barry Sophia S, Jones Kirk D, Elicker Brett M, Kim Dong Soon, Papa Feroz R, Collard Harold R, Wolters Paul J
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2012-11-01
Serier:Respiratory Research
Fag:
Idiopathic interstitial pneumonia
idiopathic pulmonary fibrosis
lung fibrosis
ER stress
apoptosis
Online adgang:http://respiratory-research.com/content/13/1/105
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