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Activation of the pentose phosphate pathway in macrophages is crucial for granuloma formation in sarcoidosis

Sarcoidosis is a disease of unknown etiology in which granulomas form throughout the body and is typically treated with glucocorticoids, but there are no approved steroid-sparing alternatives. Here, we investigated the mechanism of granuloma formation using single-cell RNA-Seq in sarcoidosis patient...

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Principais autores: Satoshi Nakamizo, Yuki Sugiura, Yoshihiro Ishida, Yoko Ueki, Satoru Yonekura, Hideaki Tanizaki, Hiroshi Date, Akihiko Yoshizawa, Teruasa Murata, Kenji Minatoya, Mikako Katagiri, Seitaro Nomura, Issei Komuro, Seishi Ogawa, Saeko Nakajima, Naotomo Kambe, Gyohei Egawa, Kenji Kabashima
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2023-12-01
Serier:The Journal of Clinical Investigation
Fag:
Dermatology
Immunology
Online adgang:https://doi.org/10.1172/JCI171088
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