Novel polymorphisms in the prion protein gene (PRNP) and stability of the resultant prion protein in different horse breeds

Abstract Prion diseases are fatal neurodegenerative disorders in which the main pathogenic event is the conversion of the cellular prion protein (PrPC) into an abnormal and misfolded isoform known as PrPSc. Most prion diseases and their susceptibility and pathogenesis are mainly modulated by the PRN...

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Detalhes bibliográficos

Principais autores:	Diego Sola, Rody Artigas, Diego R. Mediano, Pilar Zaragoza, Juan José Badiola, Inmaculada Martín-Burriel, Cristina Acín
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-10-01
Colecção:	Veterinary Research
Assuntos:	Prion disease prions transmissible spongiform encephalopathy PRNP polymorphisms horse
Acesso em linha:	https://doi.org/10.1186/s13567-023-01211-8
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