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Non-clinical evaluation of pmIL12 gene therapy for approval of the phase I clinical study

Abstract Immunotherapeutic drugs are promising medicines for cancer treatment. A potential candidate for immunotherapy is interleukin-12 (IL-12), a cytokine well known for its ability to mediate antitumor activity. We developed a plasmid encoding human IL-12 devoid of an antibiotic resistance gene (...

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Hoofdauteurs: Bostjan Markelc, Tanja Jesenko, Simona Kranjc Brezar, Masa Omerzel, Ursa Lampreht Tratar, Andrej Rencelj, Urska Matkovic, Katarina Znidar, Spela Kos, Kristina Levpuscek, Ziva Pisljar, Ursa Kesar, Tilen Komel, Tim Bozic, Aneja Tuljak, Rosana Hudej, Matjaz Peterka, Urska Kamensek, Andrej Cör, Gorana Gasljevic, Alenka Nemec Svete, Natasa Tozon, Gregor Sersa, Maja Cemazar
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Portfolio 2024-09-01
Reeks:Scientific Reports
Onderwerpen:
Plasmid DNA
Interleukin 12
Electroporation
Gene electrotransfer
CT26 colorectal carcinoma
Online toegang:https://doi.org/10.1038/s41598-024-73314-x
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