17.6% of patients in a German cohort with exocrine pancreatic cancer were diagnosed with a genetic tumor syndrome—a case for universal genetic testing?

Background: Yields for (likely) pathogenic germline variants (PGVs) in cancer predisposition genes (CPGs) in pancreatic cancer (PCA) cases range from 5% to 10% in initial literature to 15% to 20% in recent literature. PGVs can impact therapy recommendations and cancer surveillance for individuals an...

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Autores principales:	D. William, M. Bermúdez, A. Kübler, C. Kahlert, M. Distler, J. Weitz, S. Uhrig, M. Fröhlich, B. Hutter, D. Aust, G. Baretton, P. Wimberger, K. Kast, C. Meisel, L. Gieldon, J. Porrmann, J. Wagner, M. Arlt, M. Franke, J. Fischer, K. Hackmann, S. Kreutzfeldt, A. Mock, C.E. Heilig, D.B. Lipka, M.-V. Teleanu, R.F. Schlenk, B. Brors, D. Hübschmann, N. Paramasivam, D. Richter, K. Beck, K. Pfütze, I. Buchhalter, W. Weichert, T. Herold, K. Spiekermann, P.J. Jost, U. Keilholz, F. Klauschen, S. Bauer, J.T. Siveke, T. Kindler, M. Boerries, A.L. Illert, M. Bitzer, K. Schulze-Osthoff, P. Schirmacher, A. Stenzinger, P. Horak, C. Heining, G. Folprecht, S. Fröhling, H. Glimm, E. Schröck, A. Jahn
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2025-09-01
Colección:	ESMO Gastrointestinal Oncology
Materias:	familial pancreatic cancer germline testing hereditary cancer genetic tumor syndromes targeted therapy pancreatic adenocarcinoma
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2949819825000871
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