Spatial interaction mapping of PD-1/PD-L1 in head and neck cancer reveals the role of macrophage-tumour barriers associated with immunotherapy response

Abstract Background Mucosal head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage, where the prognosis is poor due to the high rates of recurrence and metastasis. With approximately one million new cases projected in 2024, worldwide mortality of HNSCC is estimated to...

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Detalhes bibliográficos

Principais autores:	Vahid Yaghoubi Naei, Rafael Tubelleza, James Monkman, Habib Sadeghirad, Meg L. Donovan, Tony Blick, Agata Wicher, Sara Bodbin, Amelie Viratham, Robert Stad, Subham Basu, Caroline Cooper, Catherine Barnett, Ken O’Byrne, Rahul Ladwa, Majid Ebrahimi Warkiani, Brett G. M. Hughes, Arutha Kulasinghe
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-02-01
coleção:	Journal of Translational Medicine
Assuntos:	Head and neck cancer Proximity ligation assay Immunotherapy Macrophages Cellular interactions PD-L1 interactions
Acesso em linha:	https://doi.org/10.1186/s12967-025-06186-y
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