Shenzhi Jiannao formula ameliorates vascular dementia in vivo and in vitro by inhibition glutamate neurotoxicity via promoting clathrin-mediated endocytosis

Abstract Background Synaptic damage and glutamate excitotoxicity have been implicated in the pathogenesis of vascular dementia (VD). Clathrin, RAB5B and N-methyl-d-aspartic acid receptor 1 (NMDAR1) proteins play a vital role in endocytosis of synaptic vesicles in neurons and glutamate over accumulat...

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Detalhes bibliográficos

Principais autores:	Danfeng Tian, Yangyang Guo, Dandan Zhang, Qiang Gao, Ganlu Liu, Jingfeng Lin, Ze Chang, Yuchun Wang, Rui Su, Zhenyun Han
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-07-01
Colecção:	Chinese Medicine
Assuntos:	Shenzhi Jiannao formula Vascular dementia Clathrin-mediated endocytosis Glutamate Neurotoxicity Cognition recovery
Acesso em linha:	https://doi.org/10.1186/s13020-021-00477-4
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