ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42

Abstract Background The extravasation capability of hepatocellular carcinoma (HCC) cells plays a vital role in distant metastasis. However, the underlying mechanism of extravasation in HCC lung metastasis remains largely unclear. Methods The expression of ARHGEF37 in human HCC specimens and HCC cell...

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Autori principali:	Xin Zhang, Liangliang Ren, Junhua Wu, Rongni Feng, Yunyang Chen, Ronggang Li, Meimei Wu, Mingzhu Zheng, Xing Gui Wu, Wanjun Luo, Hongle He, Yanming Huang, Miaoling Tang, Jun Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2022-07-01
Serie:	Journal of Experimental & Clinical Cancer Research
Soggetti:	Extravasation Rho guanine nucleotide exchange factor HCC Metastasis
Accesso online:	https://doi.org/10.1186/s13046-022-02441-y
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