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Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patients

Summary: Background: SARS-CoV-2 targets endothelial cells through the angiotensin-converting enzyme 2 receptor. The resulting endothelial injury induces widespread thrombosis and microangiopathy. Nevertheless, early specific markers of endothelial dysfunction and vascular redox status in COVID-19 p...

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Principais autores: Virginie Montiel, Irina Lobysheva, Ludovic Gérard, Marjorie Vermeersch, David Perez-Morga, Thomas Castelein, Jean-Baptiste Mesland, Philippe Hantson, Christine Collienne, Damien Gruson, Marie-Astrid van Dievoet, Alexandre Persu, Christophe Beauloye, Mélanie Dechamps, Leïla Belkhir, Annie Robert, Marc Derive, Pierre-François Laterre, A.H.J Danser, Xavier Wittebole, Jean-Luc Balligand
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2022-03-01
Serier:EBioMedicine
Fag:
SARS-CoV-2
Nitric oxide
Angiotensin II
Microvascular thrombosis
Oxidative stress
Endothelial dysfunction
Online adgang:http://www.sciencedirect.com/science/article/pii/S2352396422000779
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