Bayesian multi-study non-negative matrix factorization for mutational signatures
Abstract Mutational signatures are typically identified from tumor genome sequencing data using non-negative matrix factorization (NMF). However, existing NMF techniques only decompose a single dataset, limiting rigorous comparisons of signatures across conditions. We propose a Bayesian NMF method t...
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2025-04-01
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| coleção: | Genome Biology |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1186/s13059-025-03563-0 |
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