Cytochrome P450 Enzyme Design by Constraining the Catalytic Pocket in a Diffusion Model

Although cytochrome P450 enzymes are the most versatile biocatalysts in nature, there is insufficient comprehension of the molecular mechanism underlying their functional innovation process. Here, by combining ancestral sequence reconstruction, reverse mutation assay, and progressive forward accumul...

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Autors principals:	Qian Wang, Xiaonan Liu, Hejian Zhang, Huanyu Chu, Chao Shi, Lei Zhang, Jie Bai, Pi Liu, Jing Li, Xiaoxi Zhu, Yuwan Liu, Zhangxin Chen, Rong Huang, Hong Chang, Tian Liu, Zhenzhan Chang, Jian Cheng, Huifeng Jiang
Format:	Artigo
Idioma:	Inglês
Publicat:	American Association for the Advancement of Science (AAAS) 2024-01-01
Col·lecció:	Research
Accés en línia:	https://spj.science.org/doi/10.34133/research.0413
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