Molecular mechanisms of dose-dependent regulation of hepatic lipid metabolism by BaP through modulation of AhR binding to XRE1 or XRE3

Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon and a potent environmental pollutant, has been implicated in the dysregulation of lipid metabolism and metabolic diseases, warranting investigation into its effects on liver functions, particularly regarding fibroblast growth factor 21 (FGF21)...

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Hlavní autoři:	Mengdi Zhang, Xiaoli Lv, Chaojie Wang, Lei Wang, Han Wang, Xue Wang, Yulu Du, Jun Li, Xiuli Han, Lei Fan, Yuxia Hu, Tuya Bai, Weizhong Huangfu, Fuhou Chang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-07-01
Edice:	Frontiers in Pharmacology
Témata:	benzo[a]pyren fibroblast growth factor 21 aryl hydrocarbon receptor xenobiotic response element 1 xenobiotic response element 3 hepatic lipid metabolism
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1595566/full
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