Single-Cell Profiling Reveals Immune-Based Mechanisms Underlying Tumor Radiosensitization by a Novel Mn Porphyrin Clinical Candidate, MnTnBuOE-2-PyP⁵⁺ (BMX-001)

Manganese porphyrins reportedly exhibit synergic effects when combined with irradiation. However, an in-depth understanding of intratumoral heterogeneity and immune pathways, as affected by Mn porphyrins, remains limited. Here, we explored the mechanisms underlying immunomodulation of a clinical can...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Sun Up Noh, Jinyeong Lim, Sung-Won Shin, Yeeun Kim, Woong-Yang Park, Ines Batinic-Haberle, Changhoon Choi, Won Park
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2024-04-01
Rangatū:	Antioxidants
Ngā marau:	Mn porphyrin clinical candidate MnTnBuOE-2-PyP<sup>5+</sup> (BMX-001 MnBuOE) single-cell RNA sequencing tumor heterogeneity tumor microenvironment
Urunga tuihono:	https://www.mdpi.com/2076-3921/13/4/477
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!