HiCBin: binning metagenomic contigs and recovering metagenome-assembled genomes using Hi-C contact maps

Abstract Recovering high-quality metagenome-assembled genomes (MAGs) from complex microbial ecosystems remains challenging. Recently, high-throughput chromosome conformation capture (Hi-C) has been applied to simultaneously study multiple genomes in natural microbial communities. We develop HiCBin,...

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Auteurs principaux:	Yuxuan Du, Fengzhu Sun
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2022-02-01
Collection:	Genome Biology
Sujets:	Metagenomic Hi-C Zero-inflated negative binomial normalization Spurious contact detection Leiden clustering Potts model Contig binning
Accès en ligne:	https://doi.org/10.1186/s13059-022-02626-w
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