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Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts

Abnormal lung development can cause congenital pulmonary cysts, the mechanisms of which remain largely unknown. Although the cystic lesions are believed to result directly from disrupted airway epithelial cell growth, the extent to which developmental defects in lung mesenchymal cells contribute to...

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Autori principali: Yongfeng Luo, Ke Cao, Joanne Chiu, Hui Chen, Hong-Jun Wang, Matthew E Thornton, Brendan H Grubbs, Martin Kolb, Michael S Parmacek, Yuji Mishina, Wei Shi
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications Ltd 2024-06-01
Serie:eLife
Soggetti:
BMP signaling
lung mesenchymal cells
pulmonary cysts
lung development
Bmpr1a
airway smooth muscle cells
Accesso online:https://elifesciences.org/articles/91876
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