PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer

Background: Chemotherapy is currently evaluated in order to enhance the efficacy of immune checkpoint blockade (ICB) therapy in colorectal cancer. However, the mechanisms by which these drugs could synergize with ICB remains unclear. The impact of chemotherapy on the PD-1/PD-L1 pathway and the resul...

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Hauptverfasser:	Magalie Dosset, Thaiz Rivera Vargas, Anaïs Lagrange, Romain Boidot, Frédérique Végran, Aurélie Roussey, Fanny Chalmin, Lucile Dondaine, Catherine Paul, Elodie Lauret Marie-Joseph, François Martin, Bernhard Ryffel, Christophe Borg, Olivier Adotévi, François Ghiringhelli, Lionel Apetoh
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2018-06-01
Schriftenreihe:	OncoImmunology
Schlagworte:	chemotherapy colorectal cancer, adaptive immune resistance pd-1/pd-l1 pathway immunotherapy cd8 t cells
Online-Zugang:	http://dx.doi.org/10.1080/2162402X.2018.1433981
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