<i>N</i>-[1,3-Dialkyl(aryl)-2-oxoimidazolidin-4-ylidene]-aryl(alkyl)sulphonamides as Novel Selective Human Cannabinoid Type 2 Receptor (hCB2R) Ligands; Insights into the Mechanism of Receptor Activation/Deactivation

Cannabinoid type 1 (hCB1) and type 2 (hCB2) receptors are pleiotropic and crucial targets whose signaling contributes to physiological homeostasis and its restoration after injury. Being predominantly expressed in peripheral tissues, hCB2R represents a safer therapeutic target than hCB1R, which is h...

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Detalles Bibliográficos

Principais autores:	Eleonora Gianquinto, Federica Sodano, Barbara Rolando, Magdalena Kostrzewa, Marco Allarà, Ali Mokhtar Mahmoud, Poulami Kumar, Francesca Spyrakis, Alessia Ligresti, Konstantin Chegaev
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2022-11-01
Series:	Molecules
Assuntos:	cannabinoid receptors hCB2R selective ligands drug design in silico simulations mechanism of receptor activation
Acceso en liña:	https://www.mdpi.com/1420-3049/27/23/8152
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