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Longitudinal profiling of the intestinal microbiome in children with cystic fibrosis treated with elexacaftor-tezacaftor-ivacaftor

ABSTRACT The intestinal microbiome influences growth and disease progression in children with cystic fibrosis (CF). Elexacaftor-tezacaftor-ivacaftor (ELX/TEZ/IVA), the newest pharmaceutical modulator for CF, restores the function of the pathogenic mutated CF transmembrane conductance regulator (CFTR...

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Main Authors: Seth A. Reasoner, Rachel Bernard, Adam Waalkes, Kelsi Penewit, Janessa Lewis, Andrew G. Sokolow, Rebekah F. Brown, Kathryn M. Edwards, Stephen J. Salipante, Maria Hadjifrangiskou, Maribeth R. Nicholson
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2024-02-01
Series:mBio
Subjects:
cystic fibrosis
CFTR modulator
microbiome
elexacaftor
ivacaftor
tezacaftor
Online Access:https://journals.asm.org/doi/10.1128/mbio.01935-23
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