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The Stringent Response Inhibits 70S Ribosome Formation in Staphylococcus aureus by Impeding GTPase-Ribosome Interactions

ABSTRACT During nutrient limitation, bacteria produce the alarmones (p)ppGpp as effectors of a stress signaling network termed the stringent response. RsgA, RbgA, Era, and HflX are four ribosome-associated GTPases (RA-GTPases) that bind to (p)ppGpp in Staphylococcus aureus. These enzymes are cofacto...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Daniel J. Bennison, Jose A. Nakamoto, Timothy D. Craggs, Pohl Milón, John B. Rafferty, Rebecca M. Corrigan
Hōputu: Artigo
Reo:Inglês
I whakaputaina: American Society for Microbiology 2021-12-01
Rangatū:mBio
Ngā marau:
Urunga tuihono:https://journals.asm.org/doi/10.1128/mBio.02679-21
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