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Effects of High Dose Methotrexate and Delayed Elimination on Myelotoxicity Progression in Children with Acute Lymphoblastic Leukemia

Background and study aim: Methotrexate (MTX) as an antineoplastic agent inhibits dihydrofolate reductase. The frequency of high dose methotrexate (HDMTX) associated toxicity is variable. In this study we investigate the frequency of myelosuppression following 5 and 9 days of HDMTX infusion and MTX d...

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Autors principals: Hassan El Fayoumi, Usama El-Safy, Manar Fathy, Omar El-Azzazy
Format: Artigo
Idioma:Inglês
Publicat: Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department 2017-03-01
Col·lecció:Afro-Egyptian Journal of Infectious and Endemic Diseases
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Accés en línia:https://aeji.journals.ekb.eg/article_8993_83abd9b8c54cc998d929f2199ba7069f.pdf
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