Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice

The introduction of megabase-sized large DNA fragments into the germline has been a difficult task. Although microcell-mediated chromosome transfer into mouse embryonic stem cells (ESCs) allows the production of transchromosomic mice, ESCs have unstable karyotypes and germline transmission is unreli...

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Detalhes bibliográficos

Principais autores:	Takashi Shinohara, Kanako Kazuki, Narumi Ogonuki, Hiroko Morimoto, Shogo Matoba, Kei Hiramatsu, Kazuhisa Honma, Teruhiko Suzuki, Takahiko Hara, Atsuo Ogura, Mitsuo Oshimura, Mito Kanatsu-Shinohara, Yasuhiro Kazuki
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2017-10-01
coleção:	Stem Cell Reports
Assuntos:	spermatogenesis karyotype artificial chromosome spermatogonia
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213671117303697
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