Hypermethylation of the non-imprinted maternal MEG3 and paternal MEST alleles is highly variable among normal individuals.

Imprinted genes show parent-specific activity (functional haploidy), which makes them particularly vulnerable to epigenetic dysregulation. Here we studied the methylation profiles of oppositely imprinted genes at single DNA molecule resolution by two independent parental allele-specific deep bisulfi...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Larissa Haertle, Anna Maierhofer, Julia Böck, Harald Lehnen, Yvonne Böttcher, Matthias Blüher, Martin Schorsch, Ramya Potabattula, Nady El Hajj, Silke Appenzeller, Thomas Haaf
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2017-01-01
Schriftenreihe:	PLoS ONE
Online-Zugang:	http://europepmc.org/articles/PMC5576652?pdf=render
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