Microvascular endothelial scavenger receptor class B type I protects against heart failure with preserved ejection fraction by inhibiting T-cell cardiotropism

Abstract Cardiac microvascular endothelial cells (CMECs) dysfunction is a well-recognized mediator of heart failure with preserved ejection fraction (HFpEF), but the underlying mechanism remains unclear. Here we find that scavenger receptor class B type I (SR-B1) is predominantly expressed in CMECs...

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Hlavní autoři:	Yufei Wu, Xiaomei Yang, Yu Bai, Chenze Li, Peng Wang, Qing Xu, Hui Li, Xiaoli Rao, Yangkai Xu, Jie Chen, Huanhuan Cao, Qi Zhang, Mingming Zhao, Rui Zhan, Xue Fan, Yuedong Hou, Jie Liu, Hong S Lu, Tianyun Wang, Wei Dong Gao, Linzhang Huang, Han Xiao, Lingyun Zu, Alan Daugherty, Mingguo Xu, Lemin Zheng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2026-04-01
Edice:	EMBO Molecular Medicine
Témata:	Heart Failure with Preserved Ejection Fraction Cardiac Microvascular Endothelial Dysfunction Scavenger Receptor Class B Type I (SR-B1) Chemokine C-X-C Motif Chemokine Ligand 10 (CXCL10)
On-line přístup:	https://doi.org/10.1038/s44321-026-00405-9
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