Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells regulates age-dependent changes in sperm DNA methylation

Over the past several decades, a trend toward delayed childbirth has led to increases in parental age at the time of conception. Sperm epigenome undergoes age-dependent changes increasing risks of adverse conditions in offspring conceived by fathers of advanced age. The mechanism(s) linking paternal...

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Главные авторы:	Saira Amir, Olatunbosun Arowolo, Ekaterina Mironova, Joseph McGaunn, Oladele Oluwayiose, Oleg Sergeyev, J Richard Pilsner, Alexander Suvorov
Формат:	Artigo
Язык:	Inglês
Опубликовано:	eLife Sciences Publications Ltd 2024-09-01
Серии:	eLife
Предметы:	rejuvenation aging DNA methylation epigenetic mTOR sperm
Online-ссылка:	https://elifesciences.org/articles/90992
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