Chloride intracellular channel (CLIC) protein function in S1P-induced Rac1 activation requires membrane localization of the C-terminus, but not thiol-transferase nor ion channel activities

We have established a novel and evolutionarily-conserved function for chloride intracellular channel proteins (CLICs) in regulating Rho/Rac GTPases downstream of G protein-coupled receptors (GPCRs). Endothelial CLIC1 and CLIC4 are rapidly and transiently re-localized from the cytoplasm to the plasma...

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Principais autores:	De Yu Mao, Jordan J. Jesse, Daniel D. Shaye, Jan Kitajewski
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2025-04-01
סדרה:	Frontiers in Cell and Developmental Biology
נושאים:	CLIC1 CLIC4 RhoA Rac1 sphingosine-1-phosphate S1P receptor
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1565262/full
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