Structural Investigation of Therapeutic Antibodies Using Hydroxyl Radical Protein Footprinting Methods

Commercial monoclonal antibodies are growing and important components of modern therapies against a multitude of human diseases. Well-known high-resolution structural methods such as protein crystallography are often used to characterize antibody structures and to determine paratope and/or epitope b...

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Główni autorzy:	Corie Y. Ralston, Joshua S. Sharp
Format:	Artigo
Język:	Inglês
Wydane:	MDPI AG 2022-11-01
Seria:	Antibodies
Hasła przedmiotowe:	hydroxyl radical footprinting structural mass spectrometry fast photochemical oxidation of proteins (FPOP) flash oxidation (FOX) X-ray footprinting with mass spectrometry (XFMS) therapeutic antibody structure
Dostęp online:	https://www.mdpi.com/2073-4468/11/4/71
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