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TP53 status is associated with thrombospondin1 expression in vitro

Objectives: To elucidate the association between thrombospondin1 (THBS1) expression and TP53 status and THBS1 promoter methylation in epithelial ovarian cancer (EOC). Methods: EOC cell lines with known TP53 status were analyzed for THBS1 gene expression using Affymetrix U133 microarrays and promo...

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Main Authors: Angeles eAlvarez Secord, Marcus Q Bernardini, Gloria eBroadwater, Lisa A Grace, Zhiqing eHuang, Tsukasa eBaba, Eiji eKondo, Gregory eSfakianos, Laura J Havrilesky, Susan K Murphy
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Oncology
Subjects:
Angiogenesis Inhibitors
Methylation
Thrombospondins
ovarian cancer
TP53
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00269/full
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