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Modeling rebound bone loss following denosumab discontinuation and sequential zoledronate therapy in TgRANKL osteoporotic mice

BackgroundReceptor activator of nuclear factor-κB ligand (RANKL) plays a central role in regulating osteoclast formation and bone resorption, while its inhibition by the monoclonal antibody denosumab serves as an effective antiresorptive treatment for postmenopausal osteoporosis. However, denosumab...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Vagelis Rinotas, Eleftheria-Dimitra Ntouskou, Melina Dragolia, Vasileios Ntafis, Maria P. Yavropoulou, Athanasios D. Anastasilakis, Polyzois Makras, Eleni Douni
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2026-02-01
Rangatū:Frontiers in Endocrinology
Ngā marau:
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fendo.2026.1783656/full
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