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Quantitative and qualitative mutational impact of ionizing radiation on normal cells

Summary: The comprehensive genomic impact of ionizing radiation (IR), a carcinogen, on healthy somatic cells remains unclear. Using large-scale whole-genome sequencing (WGS) of clones expanded from irradiated murine and human single cells, we revealed that IR induces a characteristic spectrum of sho...

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Päätekijät: Jeonghwan Youk, Hyun Woo Kwon, Joonoh Lim, Eunji Kim, Taewoo Kim, Ryul Kim, Seongyeol Park, Kijong Yi, Chang Hyun Nam, Sara Jeon, Yohan An, Jinwook Choi, Hyelin Na, Eon-Seok Lee, Youngwon Cho, Dong-Wook Min, HyoJin Kim, Yeong-Rok Kang, Si Ho Choi, Min Ji Bae, Chang Geun Lee, Joon-Goon Kim, Young Seo Kim, Tosol Yu, Won-Chul Lee, Jong-Yeon Shin, Dong Soo Lee, Tae-You Kim, Taeyun Ku, Su Yeon Kim, Joo-Hyeon Lee, Bon-Kyoung Koo, Hyunsook Lee, On Vox Yi, Eon Chul Han, Ji Hyun Chang, Kyung Su Kim, Tae Gen Son, Young Seok Ju
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2024-02-01
Sarja:Cell Genomics
Aiheet:
ionizing radiation
mutational signature
structural variation
complex genomic rearrangement
single-base substitution
irradiation dose
Linkit:http://www.sciencedirect.com/science/article/pii/S2666979X24000260
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