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Single-cell transcriptome delineating asymmetric dynamics of CD4+ T and CD8+ T cell lineage commitment in human prenatal thymus

IntroductionThe thymus provides a specialized microenvironment for T cell development and selection, yet the cellular heterogeneity and molecular dynamics that govern human prenatal thymopoiesis remain incompletely characterized. MethodsWe constructed an integrative single-cell atlas of human prenat...

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Principais autores: Yang Yang, Yingpeng Yao, Shiga Jibu, Yijun Yin, Zongcheng Li, Yanli Ni, Bing Liu, Yu Lan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-05-01
Serier:Frontiers in Immunology
Fag:
CD4/CD8 lineage commitment
human prenatal thymus
selection intermediates
T cell differentiation
thymocyte development
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1823728/full
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