Thapsigargin at Non-Cytotoxic Levels Induces a Potent Host Antiviral Response that Blocks Influenza A Virus Replication

Influenza A virus is a major global pathogen of humans, and there is an unmet need for effective antivirals. Current antivirals against influenza A virus directly target the virus and are vulnerable to mutational resistance. Harnessing an effective host antiviral response is an attractive alternativ...

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Autors principals:	Leah V. Goulding, Jiayun Yang, Zhimin Jiang, Hongyu Zhang, Daniel Lea, Richard D. Emes, Tania Dottorini, Juan Pu, Jinhua Liu, Kin-Chow Chang
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2020-09-01
Col·lecció:	Viruses
Matèries:	thapsigargin endoplasmic reticulum stress unfolded protein response antiviral influenza A virus innate immunity
Accés en línia:	https://www.mdpi.com/1999-4915/12/10/1093
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