Beyond bioactivity: Chitosan macromolecular coatings on titanium surfaces drive osseointegration and immune suppression through targeted epigenetic regulation

Objective(s): To address titanium (Ti) implant failures caused by inadequate osseointegration and persistent inflammation by developing a novel dual-action coating. This coating utilizes a chitosan (CH) matrix to deliver epigenetic pharmaceuticals, 5-azacytidine (AZ) and trichostatin A (TR), onto Ti...

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Principais autores:	Rayshmi Balaji, Nagarajan Mahendirakumar, Vijitha Dayasekaran, Sriram Kaliamoorthy, Kavitha Jayavel
Format:	Artigo
Jezik:	Inglês
Izdano:	Mashhad University of Medical Sciences 2026-07-01
Serija:	Iranian Journal of Basic Medical Sciences
Teme:	anti-inflammatory agents biological macromolecules chitosan coating epigenetic pharmaceuticals osteogenic processes titanium prosthetics
Online dostop:	https://ijbms.mums.ac.ir/article_27824_6ee5bbf9f57dfe96549e3a7caf8305e3.pdf
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