Development of Pharmacophore Model for Indeno[1,2-b]indoles as Human Protein Kinase CK2 Inhibitors and Database Mining

Protein kinase CK2, initially designated as casein kinase 2, is an ubiquitously expressed serine/threonine kinase. This enzyme, implicated in many cellular processes, is highly expressed and active in many tumor cells. A large number of compounds has been developed as inhibitors comprising different...

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Autores principales:	Samer Haidar, Zouhair Bouaziz, Christelle Marminon, Tuomo Laitinen, Antti Poso, Marc Le Borgne, Joachim Jose
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2017-01-01
Colección:	Pharmaceuticals
Materias:	CK2 cancer indeno[1,2-b]indoles pharmacophore MOE ZINC database
Acceso en línea:	http://www.mdpi.com/1424-8247/10/1/8
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