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Effect of Baloxavir and Oseltamivir in Combination on Infection with Influenza Viruses with PA/I38T or PA/E23K Substitutions in the Ferret Model

ABSTRACT Amino acid substitutions I38T and E23K in the influenza polymerase acidic (PA) protein lead to reduced susceptibility to the influenza antiviral drug baloxavir. The in vivo effectiveness of baloxavir and oseltamivir for treatment of these viruses is currently unknown. Using patient-derived...

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Huvudupphov: Paulina Koszalka, Ankita George, Vijaykrishna Dhanasekaran, Aeron C. Hurt, Kanta Subbarao
Materialtyp: Artigo
Språk:Inglês
Utgiven: American Society for Microbiology 2022-08-01
Serie:mBio
Ämnen:
antiviral resistance
ferret
virus
antiviral agents
influenza
Länkar:https://journals.asm.org/doi/10.1128/mbio.01056-22
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